Underscoring the entire schedule is that the 2025 campaign will be the last in their longtime home of Highmark Stadium, where they began playing in 1973. As their new stadium across the street is scheduled to be ready for the 2026 season, the Bills have one final chance to chase Super Bowl glory in their farewell season to their 53-year home.

Every team in 2025 produced a video for social media which is a simply a fun way for them to show fans the new schedule ahead. The New York Jets were no different than anyone else. In theirs, the Bills used "AI" in a cheeky idea. Basketball legend and Hall of Famer Allen Iverson helped the team use "AI," which is Iverson's nickname.

Fresh off a heartbreaking loss to the Kansas City Chiefs in the AFC Championship Game last season, the Buffalo Bills are set to enter 2025 with Super Bowl aspirations.

ORCHARD PARK, NEW YORK - JANUARY 19: Lamar Jackson #8 of the Baltimore Ravens and Josh Allen #17 of the Buffalo Bills embrace after the AFC Divisional Playoff game at Highmark Stadium on January 19, 2025 in Orchard Park, New York. (Photo by Al Bello/Getty Images) Getty Images

Every NFL schedule presents unique challenges for teams but we picked the toughest for the Bucs on the 2025 schedule.

For starters, they won't be suffering from much jetlag in 2025—Cincinnati travels a combined 8,753 miles in 2025, the least in the league. A chunk of that travel comes early in the season, with four of their first six games away from home.

It will be an all-AFC West affair when the NFL returns to Brazil in Week 1. The Chiefs will face the Chargers on Friday, Sept. 5, at Corinthians Arena in São Paulo in a game that will stream for free on YouTube.

Regular-season success is nothing new for the Buffalo Bills with Josh Allen at quarterback and Sean McDermott as head coach. Buffalo has won at least 10 games and made the playoffs every season since 2019.