The San Francisco 49ers have a better record than the Houston Texans, but the oddsmakers have the Texans as favorites. They may be projecting the injuries to finally catch up to the 49ers. If the 49ers want to avoid this situation, the following players need to step up.

Quarterback Brock Purdy will miss his fourth straight game for the San Francisco 49ers because of a toe injury.

As expected, the San Francisco 49ers officially ruled Brock Purdy and Ricky Pearsall out. Here is the list of players who won’t suit up against the Houston Texans in Week 8: The last time the 49ers had a road game was in Tampa Bay in Week 6.