ALS is linked to toxic TDP-43 protein clumps. A new strategy targets a specific protein region. A small molecule, XL20, prevents clumping, reducing nerve damage in human cells. XL20 extended survival ...

Neuralink tested a brain implant approach that threads electrodes through the dura without cutting it open. The company says ...

A less invasive brain-computer interface is being developed to help people with impaired speech, including ALS, communicate.

Oral PrimeC for ALS significantly reduced toxic TDP-43 protein levels in a Phase 2b trial. PrimeC also slowed functional decline and extended survival by about 15 months. The treatment was well ...

Whole-body MRI (WB-MRI) may improve ALS diagnostic certainty. WB-MRI assesses muscle swelling (edema) as a marker for lower ...

Having resilience is so important to me that I’ve written several columns about it. I believe resilience — the ability to cope with and survive change — is a skill ALS patients should hone to navigate ...

Australian data links over 10% of ALS cases to known genetic mutations. The SALSA-SGC consortium collects data to understand ALS causes and progression. The project brings together seven major motor ...

I walked with our dog, Comet, on a trail in the woods behind our house. The woods felt cool out of the hot sun. Light filtered through the trees overhead as I breathed in the rich smell of summer ...

A co-designed robotic glove restored grip and independent feeding for a man with severe ALS. The soft, wearable device uses inflatable cushions, controlled by residual muscle signals. This low-cost ...

An expanded access program for Qalsody in ALS patients was feasible and well-tolerated. The program provided Qalsody to 11 ALS patients ineligible for trials. A mixed funding model, including ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disease that affects people differently, with ALS prognosis varying considerably from one person to another. The condition gradually ...

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease characterized by the progressive loss of motor neurons, nerve cells that control the voluntary muscles. This leads to overall ...