gut.bmj

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

Objective Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where ...
gut.bmj

The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study

Objective The aim of this study was to assess the correlation between serum and intestinal anti-tumour necrosis factor (TNF) levels, and their relationship to endoscopic disease activity and levels of ...
gut.bmj

Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis

Objective: Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. Evidence for treatment of the condition with antidepressants and psychological therapies is conflicting.
Gut

Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards

Background Endoscopic submucosal dissection (ESD) enables en bloc resection of early gastrointestinal cancers and provides ...
gut.bmj

Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B

Background PD-1 blockade has emerged as a promising approach for functional cure of chronic hepatitis B (CHB). Objective This study aimed to evaluate the safety profile of anti-PD-1 antibody (αPD-1), ...
Gut

Decoding intestinal metaplasia: a step towards understanding gastric tumourigenesis

Tissue epithelia maintain their lineage identity under normal conditions but occasionally undergo ‘reprogramming’ into ...
Gut

Serum creatinine as both yardstick and predictor: reading chronic kidney disease in the global CLEARED cohort

We read the global analysis of chronic kidney disease (CKD) in cirrhosis by Wong et al with great interest.1 Assembling 7040 ...
gut.bmj

Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit

5 National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals and the University of Oxford, Oxford, UK Objective Lower GI bleeding (LGIB) is a common ...
gut.bmj

Efficacy of gut-brain neuromodulators and brain-gut behaviour therapies for irritable bowel syndrome: systematic review and network meta-analysis

Background Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction, with some recommended treatments targeting brain-gut axis dysfunction. Objective To compare relative efficacy of ...
gut.bmj

Current concepts of immune based treatments for patients with HCC: from basic science to novel treatment approaches

Correspondence to Professor Tim F Greten, Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH/NCI/CCR ...
gut.bmj

Generation of gaseous sulfur-containing compounds in tumour tissue and suppression of gas diffusion as an antitumour treatment

6 Department of Periodontics and Endodontics, Tsurumi University, School of Dental Medicine, Yokohama, Kanagawa, Japan 7 Department of Physiology, Tsurumi University, School of Dental Medicine, ...
gut.bmj

Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus

Background Patients with type 2 diabetes mellitus (T2DM) have higher pancreatic cancer (PC) risk. While aspirin has chemopreventive effects on digestive cancers, its effect on PC among patients with ...