RMD Open

Development and assessment of an assisted diagnosis model using machine learning for identifying adult-onset Still’s disease in fever of unknown origin: a retrospective …

Background Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder lacking a gold-standard diagnostic ...
RMD Open

Glucocorticoid in giant cell arteritis: real-world treatment patterns over time and associated burden in a nationwide hospital-based study within the French health ins…

Objective Recent advances in giant cell arteritis (GCA) management aim to reduce glucocorticoid (GC). We described changes in ...
RMD Open

Anifrolumab, a potential treatment for ADA2 deficiency

Adenosine deaminase 2 deficiency (DADA2) is an inborn error of immunity leading to systemic vasculitis, haematological manifestations, immune deficiency and/or autoimmunity. We report the case of a 26 ...
RMD Open

Prevalence of sarcopenia in patients with rheumatoid arthritis: a cross-sectional study

Objective Sarcopenia, defined by reductions in muscle mass and strength, increases the risk of adverse outcomes in patients with rheumatoid arthritis (RA)—driven in part by chronic inflammation—and is ...
RMD Open

Rare variants in genes related to inborn errors of immunity in patients with rheumatoid arthritis and secondary immunodeficiency

Objectives Treatment of rheumatoid arthritis (RA) relies on immunomodulatory drugs that can compromise immunity, inducing secondary immunodeficiency (SID). However, features of SID, such as ...
rmdopen.bmj

Rheumatoid factor and anticitrullinated protein antibody status jointly influence the association between disease activity and cardiovascular risk in rheumatoid arthritis

Objectives Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are linked to disease activity, severity and cardiovascular risk in rheumatoid arthritis (RA). Since RA-related ...
rmdopen.bmj

Effects of biologic and targeted synthetic disease modifying antirheumatic drugs (b/tsDMARDs) on patient-reported outcome domains in rheumatoid arthritis: a systematic review ...

Introduction Evidence from head-to-head comparisons of biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) on patient-reported outcomes (PROs) in patients with rheumatoid ...
rmdopen.bmj

Development of a novel meta-polygenic risk score for risk assessment and clinical manifestation prediction in systemic lupus erythematosus

Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease with multifactorial pathogenesis. Although polygenic risk scores (PRSs) have been developed to enable ...
rmdopen.bmj

Effectiveness of exercise therapy for osteoarthritis: an overview of systematic reviews and randomised controlled trials

Data sources Medline, Embase, Epistemonikos, PEDro, Cochrane and registries from inception to 8 November 2025. Eligibility criteria Reviews comparing exercise with placebo, no intervention or other ...
rmdopen.bmj

Effects of upadacitinib or adalimumab on pain in rheumatoid arthritis and psoriatic arthritis: results from randomised phase 3 studies

Introduction Patients with rheumatoid (RA) or psoriatic (PsA) arthritis can experience debilitating pain. Methods Post hoc analyses of phase 3, double-blind studies in patients with active disease ...
rmdopen.bmj

Heterogeneity of antiphospholipid antibody profiles in a clinical cohort and association with distinct clinical features

Background The diagnosis of antiphospholipid syndrome (APS) uses standard antibodies (lupus anticoagulant (LAC), anticardiolipin antibodies (aCL) IgG/IgM, β2-glycoprotein I antibodies (β2GPI) IgG/IgM) ...
rmdopen.bmj

Discrepancies between routine sacroiliac joint MRI reporting and current expert recommendations in patients with spondyloarthritis

Background Sacroiliac joint (SIJ) MRI is commonly used in diagnosing spondyloarthritis (SpA). Current Assessment of SpondyloArthritis International Society (ASAS) recommendations on reporting SIJ MRIs ...