xCT: A Critical Molecule That Links Cancer Metabolism to ...
In recent years, the xCT molecule has been found to play an important role in tumor growth, progression, metastasis, and multidrug resistance in various types of cancer. Interestingly, …
Cystine/glutamate transporter - Wikipedia
The SLC7A11 gene encodes a sodium-independent cystine - glutamate antiporter that is chloride dependent, also known as xCT. Along with a heavy chain subunit from SLC3A2, the SLC7A11 …
SLC7A11 Gene - GeneCards | XCT Protein | XCT Antibody
Nov 14, 2025 · In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of …
xCT: A Critical Molecule That Links Cancer Metabolism to ...
Nov 4, 2020 · In recent years, the xCT molecule has been found to play an important role in tumor growth, progression, metastasis, and multidrug resistance in various types of cancer. …
The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the ...
Feb 23, 2022 · In this review, we discuss the molecular functions of SLC7A11 in normal versus diseased tissues, with a special focus on how it regulates gastrointestinal cancers. Further, we …
Cystine transporter SLC7A11/xCT in cancer: ferroptosis ...
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple …
Cystine/glutamate antiporter xCT controls skeletal muscle ...
Jul 1, 2024 · Here, we demonstrate that xCT plays a crucial role in maintaining the pool of MuSCs by supporting myoblast proliferation, whereas xCT expression is rapidly downregulated during …
xCT (SLC7A11)-mediated metabolic reprogramming promotes …
May 23, 2018 · Recent studies demonstrated that smoking could induce the expression of xCT (SLC7A11) in oral cancer cells, suggesting that overexpression of xCT may support lung …
A xCT role in tumour-associated ferroptosis shed light on ...
Oct 25, 2022 · Solute carrier family 7 member 11 (SLC7A11; also known as xCT), a key component of the cystine/glutamate antiporter, is essential for the maintenance of cellular …
Cystine transporter SLC7A11/xCT in cancer: ferroptosis ...
Oct 1, 2020 · The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is …