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In the late 18th century, smallpox was a fearsome and deadly disease that ravaged communities worldwide, with no known cure. Edward Jenner, an English physician and scientist, observed that milkmaids who previously had caught cowpox did not catch smallpox. From this observation, Jenner hypothesized that the milder cowpox virus could possibly confer immunity against the more deadly smallpox virus. Acting on his hypothesis, Jenner conducted an experiment in 1796 by inoculating an eight-year-old bo
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