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Dr. John Chia
Harrison's Internal Medicine
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Daily CRISPR Updates on Instagram: "Human enterovirus A71 (EV-A71) is a major cause of hand, foot, and mouth disease, but how it infects cells is not well known. Using CRISPR-Cas9 screening, researchers have now identified a protein critical for EV-A71 infection. Their study found that a lysosomal protein called SPNS1 is essential for EV-A71 infection because it helps move a viral component called the pocket factor into the cell’s cytosol, which allows the virus to copy its genome. When SPNS1 is
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